Individual mammalian cells have been encapsulated in silica coatings using a quick and
relatively mild process carried out in cell culture medium. The coatings contain thiol groups from molecules
left over from the synthesis process offering opportunities for
post-functionalisation. Cell
proliferation was suppressed by the silica coat which also protected the cells from
the effects of trypsin and highly toxic poly (allylamine hydrochloride). Researchers suggest that modifications of the
coating could protect cells against a variety of other stressors such as heat
and UV. The approach might ultimately be useful for
applications where cells require protection and preservation such as cell-based
sensors as well as in single-cell studies.
Cytoprotective
Silica Coating of Individual Mammalian Cells Through Bioinspired Silicification,
J. Lee et al, Angewandte Chemie
International Edition; DOI: 10.1002/anie.201402280
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