Showing posts with label biomolecular recognition. Show all posts
Showing posts with label biomolecular recognition. Show all posts

Sunday, 25 May 2014

Concerted folding and networking of short peptides

Short peptide sequences have been concomitantly folded into a specific helical conformation and networked into a single crystal co-ordination material by silver(I) co-ordination.  The new material contained two types of chiral nanochannel.  The larger of the nanochannels, with a diameter of around 2nm, offered a high degree of both chiral recognition and biomolecular recognition.  BF4- counterions in the crystalline network could be exchanged with other anions in a single-crystal-to-single-crystal transformation.

Coordination-Driven Folding and Assembly of a Short Peptide into a Protein-like Two-Nanometer-Sized Channel; T. Sawada et al, Angewandte Chemie International Edition, DOI: 10.1002/anie.201403506