Sunday, 25 May 2014
Concerted folding and networking of short peptides
Short peptide sequences have been concomitantly folded into a specific helical conformation and networked into a single crystal co-ordination material by silver(I) co-ordination. The new material contained two types of chiral nanochannel. The larger of the nanochannels, with a diameter of around 2nm, offered a high degree of both chiral recognition and biomolecular recognition. BF4- counterions in the crystalline network could be exchanged with other anions in a single-crystal-to-single-crystal transformation.
Coordination-Driven Folding and Assembly of a Short Peptide into a Protein-like Two-Nanometer-Sized Channel; T. Sawada et al, Angewandte Chemie International Edition, DOI: 10.1002/anie.201403506