Monday, 28 April 2014

Gene delivery at the bionic interface

Researchers report that intense electrical signals from the electrode array forming the interface between cochlear implant and cochlea stimulate gene delivery by electroporation.  Mesenchymal cells were transfected with genes which generated brain-derived neurotrophic factor stimulating neurite growth and improving neurite-electrode contact.  This more integrated interface could improve hearing dynamic range. 

Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear; J.L.Pinyon et al; Science Translational Medicine; 23 April 2014: 
Vol. 6, Issue 233, p. 233ra54. 

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