Researchers report that intense electrical signals from the
electrode array forming the interface between cochlear implant and cochlea
stimulate gene delivery by electroporation.
Mesenchymal cells were transfected with genes which generated
brain-derived neurotrophic factor stimulating neurite growth and improving neurite-electrode
contact. This more integrated interface
could improve hearing dynamic range.
Close-Field Electroporation Gene Delivery Using the Cochlear Implant
Electrode Array Enhances the Bionic Ear; J.L.Pinyon et
al; Science Translational Medicine; 23 April 2014:
Vol. 6, Issue 233, p. 233ra54.
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