Thursday, 24 April 2014

Mechanics of stem cell nuclei

The cross-section of most materials contracts when stretched and expands when compressed. Auxetic materials do the opposite. Researchers now show that embryonic stem cell nuclei become auxetic when they enter a metastable state prior to differentiation. Data suggest that this is driven at least in part by global chromatin decondensation.

Auxetic nuclei in embryonic stem cells exiting pluripotency; S. Pagliara et al; Nature Materials (AOP); doi:10.1038/nmat3943

No comments:

Post a Comment