Sunday, 27 April 2014

Nano-factories of DNA for safer gene delivery

Traditional gene carriers are cationic to allow efficient loading with anionic genes but these carriers are toxic limiting clinical applications.  Now researchers report neutral liposomes containing DNA and PCR components which amplify the DNA.  Transfection rates are similar to the traditional cationic vectors, but cell viability significantly improved.

DNA amplification in neutral liposomes for safe and efficient gene delivery; S. Lee et al; ACS Nano Just Accepted Manuscript; DOI: 10.1021/nn501106a

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