Cells may experience physical confinement when migrating through extracellular matrices. In confinement, processes typically associated with 2D migration e.g. actin polymerization are inhibited. Now, a chemotaxis-based microfluidic device containing microchannels of varying cross-sectional areas reveals an alternative mechanism of migration in confinement: water permeation and active and passive ion transport.
Water Permeation Drives Tumor Cell Migration in
Confined Microenvironments; K.M. Stroka et al, Cell 157, 611–623, April 24, 2014
Water Permeation Drives Tumor Cell Migration in Confined Microenvironments; K.M. Stroka et al, Cell 157, 611–623, April 24, 2014
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