Bone marrow grown within a device implanted in
a mouse resembles natural marrow, researchers reported. The tissue could be explanted whole, inserted into a lab-on-a-chip
and maintained in vitro for 7
days. The cultured marrow mimicked tissue
responses to radiation toxicity and treatment for exposure normally only observed
in vivo.
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro; Y-S Torisawa et al; Nature Methods AOP doi:10.1038/nmeth.2938
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