Inflammation-induced drug release

Researchers proposed and tested in vivo pH-responsive microspheres with PLGA-shells and NaHCO₃ / antibiotic cores for the treatment of osteomyelitis.  The acid from infected bone tissue reacted with NaHCO₃ to generate CO₂ which disrupted the PLGA shells and released the antibiotic.  Microspheres were delivered via an injectable calcium phosphate cement.

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400158/abstract

Inflammation-induced drug release by using a pH responsive

gas-generating hollow-microsphere system for the treatment of osteomyelitis; M.F. Chung et al; Advanced Healthcare Materials; DOI: 10.1002/adhm.201400158.