Monday, 5 May 2014
Inflammation-induced drug release
Researchers proposed and tested in vivo pH-responsive microspheres with PLGA-shells and NaHCO3 / antibiotic cores for the treatment of osteomyelitis. The acid from infected bone tissue reacted with NaHCO3 to generate CO2 which disrupted the PLGA shells and released the antibiotic. Microspheres were delivered via an injectable calcium phosphate cement.
Inflammation-induced drug release by using a pH responsive
gas-generating hollow-microsphere system for the treatment of osteomyelitis; M.F. Chung et al; Advanced Healthcare Materials; DOI: 10.1002/adhm.201400158.