Tuesday, 13 May 2014

Delivering siRNAs to endothelial cells

Scientists have synthesised nanoparticles which efficiently delivered siRNAs to endothelial cells in vivo and facilitated silencing of up to five different endothelial genes concurrently.  Gene expression in several other cell types was not significantly affected by the presence of the delivery agent.  The nanoparticles, made of low-molecular-weight polyamines and lipids, reduced target gene expression in multiple animal models.  In lung cancer models, primary tumour growth and metastases were both reduced. 

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight; J.E. Dahlman et al, Nature Nanotechnology, DOI: 10.1038/NNANO.2014.84.

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