Sunday, 4 May 2014

Micro-RNA sensor for cancer diagnostics

Micro-RNA-21 is overexpressed in many cancers.  A new magnetobiosensor selectively detected micro-RNA-21 at low concentrations in cancer cells and tissue samples. RNA plant-virus proteins tethered to magnetic beads captured DNA duplexes formed by adding anti-Micro-RNA-21 to the Micro-RNA-21-containing samples.  Beads were captured on screen-printed electrodes for electrochemical detection of microRNA. 

Magnetobiosensors based on viral protein p19 for micro-RNA
determination in cancer cells and tissues; S. Campuzano et al; Angewandte Chemie International Edition, DOI: 10.1002/anie.201403270 

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