Researchers have demonstrated that the upconversion of
near-infra-red laser light to visible or ultra-violet by interactions with biomolecules
in-situ makes photodynamic therapy
more effective. A known photosensitizer
was activated by both near-infra-red light and the upconverted radiation
generated by nonlinear optical processes operating in either lipid molecules or
collagen. The approach substantially increased
the efficiency with which the photosensitizer destroyed cells in vitro compared to two-photon
absorption by near-infra-red alone.
Photodynamic
therapy by in situ nonlinear photon conversion, A. V. Kachynski et al, Nature Photonics AOP, DOI:
10.1038/NPHOTON.2014.90
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