Thursday, 15 May 2014

Enhancing photodynamic therapy using biomolecules

Researchers have demonstrated that the upconversion of near-infra-red laser light to visible or ultra-violet by interactions with biomolecules in-situ makes photodynamic therapy more effective.  A known photosensitizer was activated by both near-infra-red light and the upconverted radiation generated by nonlinear optical processes operating in either lipid molecules or collagen.  The approach substantially increased the efficiency with which the photosensitizer destroyed cells in vitro compared to two-photon absorption by near-infra-red alone. 

Photodynamic therapy by in situ nonlinear photon conversion, A. V. Kachynski et al, Nature Photonics AOP, DOI: 10.1038/NPHOTON.2014.90

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